Structure/thermodynamics relationships of lectin-saccharide complexes
نویسندگان
چکیده
منابع مشابه
Structure/thermodynamics relationships of lectin-saccharide complexes: the Erythrina corallodendron case.
Molecular dynamics (MD) simulations of Erythrina corallodendron lectin binding to a monosaccharide, alpha-galactose, and a disaccharide, N-acetyl lactosamine, have been performed in order to investigate the relationship between structure and thermodynamics. A simulated annealing protocol has been used to generate ensembles of structures for the two complexes, from which both qualitative and qua...
متن کاملLectin and enzyme relationships in microbiology
Examples of inter- and intramolecular direct co-functioning of lectins and enzymes are summarized. The data indicate importance of lectin-enzyme relationships in molecular and clinical microbiology and medical biotechnology. Lectin-enzyme relationships have extended prospects in medicine and biotechnology.
متن کاملIntrinsic fluorescence studies on saccharide binding to Artocarpus integrifolia lectin.
The combining region of Artocarpus integrifolia lectin has been studied by using the ligand-induced changes in the fluorescence of the lectin. The saccharide binding properties of the lectin show that C-1, C-2, C-4, and C-6 hydroxyl groups of D-galactose are important loci for sugar binding. The alpha-anomer of galactose binds more strongly than its beta-counterpart. Inversion in the configurat...
متن کاملlectin and enzyme relationships in microbiology
examples of inter- and intramolecular direct co-functioning of lectins and enzymes are summarized. the data indicate importance of lectin-enzyme relationships in molecular and clinical microbiology and medical biotechnology. lectin-enzyme relationships have extended prospects in medicine and biotechnology.
متن کاملThe crystal structure of a novel mammalian lectin, Ym1, suggests a saccharide binding site.
Ym1, a secretory protein synthesized by activated murine peritoneal macrophages, is a novel mammalian lectin with a binding specificity to GlcN. Lectins are responsible for carbohydrate recognition and for mediating cell-cell and cell-extracellular matrix interactions in microbes, plants, and animals. Glycosaminoglycan heparin/heparan sulfate binding ability was also detected in Ym1. We report ...
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ژورنال
عنوان ژورنال: European Journal of Biochemistry
سال: 2000
ISSN: 0014-2956
DOI: 10.1046/j.1432-1327.2000.01505.x